Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6
نویسندگان
چکیده
منابع مشابه
Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6
Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently. It was recently shown that transcription from the HBV genome (covalently-closed circular DNA, cccDNA) is inhibited by the structural maintenance of chromosome 5/6 complex (Smc5/6), and that a key function of HBx is to redirect the DNA-dam...
متن کاملIn Silico Prediction and Docking of Tertiary Structure of Multifunctional Protein X of Hepatitis B Virus
Hepatitis B virus (HBV) infection is a universal health problem and may result into acute, fulminant, chronic hepatitis liver cirrhosis, or hepatocellular carcinoma. Sequence for protein X of HBV was retrieved from Uniprot database. ProtParam from ExPAsy server was used to investigate the physicochemical properties of the protein. Homology modeling was carried out using Phyre2 server, and refin...
متن کاملHepatitis B Virus X Protein and Hepatocarcinogenesis
Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic ...
متن کاملMutations at Nucleotide 1762, 1764 and 1766 of Hepatitis B Virus X Gene in Patients with Chronic Hepatitis B and Hepatitis B-Related Cirrhosis
Abstract Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...
متن کاملrpb۵-mediating protein suppresses hepatitis b virus (hbv) transcription and replication by counteracting the transcriptional activation of hepatitis b virus x protein in hbv replication mouse model
conclusions our study demonstrated that a low dose of rmp could inhibit hbv transcription and replication, which is dependent on the appearance of hbx in vivo. results rpb5-mediating protein could inhibit hbv transcription and replication in groups transfected with the 1.2 wt and hbx. the inhibitory effect disappeared in the 1.2x (-) groups, yet it reappeared in the groups co-transfected with 1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2017
ISSN: 1999-4915
DOI: 10.3390/v9040069